Side Effects Of Letrozole

Letrozole is an orally active medication that is most commonly sold as brand Femara. But it can be found as numerous other brands as well. This is an anti estrogen and more specifically an Aromatase Inhibitor (AI) and is often referred to as the most powerful AI on the market.

The compound is used for lowering estrogen levels in the body. That’s why people should use it in proper manners and for proper needs.

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Avoiding Letrozole Side Effects

Is extremely important to learn how to dose Letrozole properly in order to avoid receiving negative side effects. Because side effects of Letrozole (Femara) are directly related to its dosage.

Taken into consideration that Letrozole is considered the most powerful Aromatase Inhibitor (AI) out there compared to Arimidex (Anastrozole) or Aromasin (Exemestane), is very important to understand that the compound should be used for the purpose of controlling estrogen and not eliminating estrogen.

Letrozole should be used for controlling estrogen levels because a too high suppression of estrogen in the body is going to lead to different issues and they are usually the side effects of Letrozole. The compound is most often given to women in medical settings, nonetheless, the compound is very popular among bodybuilders taken into consideration that a lot of steroids are converted into estrogen and they may end up with too high estrogen issues.

Letrozole (or other AIs) are used during such cycles to lower estrogen to normal range and avoid estrogenic related issues.

The good news is that males are generally tolerating the compound very well. They are responding differently compared to women and females would have a greater impact of using Letrozole (Femara) than men.

With this being said, men running Femara (Letrozole) might not get any side effects at all, or get them very tolerable.

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Side Effects of Letrozole Associated With Estrogen Elimination

Keep in mind that if you’re going to overdo Letrozole then you would suppress too much estrogen and although this may sound like a female hormone, this hormone is extremely popular for males too. That’s why, almost all Letrozole side effects are actually a result of too sharp, too much, or too long estrogen reduction in the body.

In fact, Letrozole side effects are very similar to any other Aromatase Inhibitors (AIs) taken into consideration that they are all working the same way of reducing estrogen by inhibiting aromatase enzymes.

Examples of Letrozole Side Effects

So, taking too much leads to Letrozole side effects. Better make sure to use it the best possible way.

Some side effects of Letrozole reported by bodybuilders:

  • Weakness
  • Fatigue
  • Headaches
  • Depression
  • Low libido
  • Inability to get an erection
  • Joint issues
  • Night sweats
  • Negative cholesterol effects
  • Estrogen rebound when stopping Femara (Letrozole)

The side effects mentioned here are associated with low estrogen levels. This hormone is affecting various parts of the body.

Estrogen Importance

For example, estrogen is important for bone mineralization. If estrogen is suppressed for too long, bone mineral density may decrease leading to osteoporosis and bone pains. That’s why there are some bodybuilders who notice that they receive bone and joint pains. Nonetheless, when you stop administering Femara (Letrozole) this side effect disappears.

Another example – estrogen is playing a vital role in the proper function of the Central Nervous System (CNS) and in case there’s not enough of it, the individual might receive such symptoms as weakness, headaches, fatigue, night sweats, and others.

Estrogen is a very important hormone for cholesterol too. If you use too much and/ or for too long Letrozole, then it surely may lead to a reduction of HDL (good) cholesterol and an increase in LDL (bad) cholesterol values because you don’t have enough estrogen. Because of a negative impact on cholesterol, it increases the risk of Cardiovascular Diseases too.

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  • Is important to understand that estrogen is not a “female” hormone only. The hormone helps men to grow muscles and get stronger. Is also important for erection and sex drive. With this being said, if you want to keep growing muscles – you better have estrogen in the normal range.

Estrogen Rebound

It was also mentioned about estrogen rebound. This side effect of Letrozole might occur when you actually stop its administration and the estrogen is increasing again and may increase way too much, offering the other way around – too high estrogen related issues. The reason why you started using Letrozole in the first place.

To lower chances of this side effect of Letrozole from occurring – you could slowly stop the administration of the compound or add a low dosage of the non suicidal aromatase inhibitor at the end of the cycle (AromasinExemestane).

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